ACTION OF PHENYLBUTAZONE, CYCLOPHOSPHAMIDE AND PREDNACINOLONE ON PLEURISY DUE TO BORDETELLA-PERTUSSIS HYPERSENSITIVITY IN RAT

  • 1 January 1978
    • journal article
    • research article
    • Vol. 235  (1) , 165-169
Abstract
Phenylbutazone, cyclophosphamide and prednacinolone acetonide, administered around the period of challenge reduced the exudate of pleurisy due to [killed] Bordetella pertussis hypersensitivity in the rat. The results on the leukocytes of the exudate are different depending on the class of product studied. Phenylbutazone only slightly reduced the number of mononuclear cells. Both the immunosuppressive and the corticoid induced a clear decrease in the total leukocyte number. While prednacinolone effects were nearly equally distributed among mononuclears and polynuclears, cyclophosphamide was mainly active on mononuclears.