Reverse gyrase—a topoisomerase which introduces positive superhelical turns into DNA
- 1 June 1984
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 309 (5970) , 677-681
- https://doi.org/10.1038/309677a0
Abstract
An enzymatic activity which converts closed circular DNA into a positively supercoiled form is present in cellular extracts of Sulfolobus, an acidothermophilic archaebacterium. This novel enzyme is a type II DNA topoisomerase and is active only at temperatures > 55.degree. C in the presence of ATP and Mg2+.Keywords
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