Inhibition of CNS myelin developmentin vivo by implantation of anti-GalC hybridoma cells
- 1 November 1994
- journal article
- research article
- Published by Springer Nature in Journal of Neurocytology
- Vol. 23 (11) , 699-707
- https://doi.org/10.1007/bf01181644
Abstract
Implantation of hybridoma cells that secrete a monoclonal antigalactocerebroside into the dorsal columns of ⩽ 9-day-old rat spinal cord results in failure of development of dorsal column myelin in the vicinity of the implant. Clusters of apparently undamaged amyelinated axons remain among the hybridoma cells. Ventral myelin is unaffected. These in vivo results support antibody-mediated inhibition of myelin formation as a potential mechanism underlying failure of remyelination in multiple sclerosis.Keywords
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