Modelling of the blood–brain barrier in drug discovery and development
Top Cited Papers
- 1 August 2007
- journal article
- review article
- Published by Springer Nature in Nature Reviews Drug Discovery
- Vol. 6 (8) , 650-661
- https://doi.org/10.1038/nrd2368
Abstract
The market for neuropharmaceuticals is potentially one of the largest sectors of the global pharmaceutical market owing to the increase in average life expectancy and the fact that many neurological disorders have been largely refractory to pharmacotherapy. The brain is a delicate organ that can efficiently protect itself from harmful compounds and precisely regulate its microenvironment. Unfortunately, the same mechanisms can also prove to be formidable hurdles in drug development. An improved understanding of the regulatory interfaces that exist between blood and brain may provide novel and more effective strategies to treat neurological disorders.Keywords
This publication has 113 references indexed in Scilit:
- Targeted delivery of proteins across the blood–brain barrierProceedings of the National Academy of Sciences, 2007
- Development of a Humanized In Vitro Blood–Brain Barrier Model to Screen for Brain Penetration of Antiepileptic DrugsEpilepsia, 2007
- Recombinant Desmodus rotundus Salivary Plasminogen Activator Crosses the Blood–Brain Barrier Through a Low-Density Lipoprotein Receptor-Related Protein-Dependent Mechanism Without Exerting Neurotoxic EffectsStroke, 2007
- Differentiating embryonic neural progenitor cells induce blood–brain barrier propertiesJournal of Neurochemistry, 2006
- Oxygen Glucose Deprivation Switches the Transport of tPA Across the Blood–Brain Barrier From an LRP-Dependent to an Increased LRP-Independent ProcessStroke, 2005
- In Search of the Astrocytic Factor(s) Modulating Blood–Brain Barrier Functions in Brain Capillary Endothelial Cells In VitroCellular and Molecular Neurobiology, 2005
- Intercommunications between brain capillary endothelial cells and glial cells increase the transcellular permeability of the blood–brain barrier during ischaemiaJournal of Neurochemistry, 2002
- Blood–brain barrier breakdown in septic encephalopathy and brain tumours*Journal of Anatomy, 2002
- Vascular Genomics of the Human BrainJournal of Cerebral Blood Flow & Metabolism, 2002
- Hydrocortisone Reinforces the Blood–Brain Barrier Properties in a Serum Free Cell Culture SystemBiochemical and Biophysical Research Communications, 1998