Relationship between Cerebral Blood Volume and CSF Pressure during Anesthesia with Isoflurane or Fentanyl in Dogs

Open Access
Publisher Website
Google Scholar
Abstract
Cerebral blood volume (CBV) and intracranial pressure (ICP) were examined in dogs during 3.5 h anesthesia with isoflurane (1.4% expired) or fentanyl (continuous i.v. infusion), and after decreasing the concentration of isoflurane to < 0.15% expired or discontinuing administration of fentanyl. Isoflurane (1.4%) increased CBV 9-11% for > 3 h but increased ICP for only the first 21.7 .+-. 1.4 min (mean .+-. SEM [standard error of the mean]). Fentanyl decreased CBV 7-10% for > 3 h but decreased ICP for only the first 20.3 .+-. 2.7 min. Because both halothane or enflurane increase ICP for > 3 h in this model, both isoflurane or fentanyl may be preferred to halothane or enflurane for patients at risk for increased ICP.