Proteolytic, Hypotensive and Thromboplastic Properties of Hypochlorite Treated Trypsin.

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Abstract
Treatment of commercial trypsin with suitable amts. of Na hypochlorite greatly diminishes the hypotensive effect of the enzyme while its proteolytic activity is increased by approx. 50%. Similar changes result from treatment with hydrogen peroxide. Hypochlorite-treated trypsin possesses a marked thromboplastic effect. Heparin prevents fatal embolism which usually results from the intraven. injn. of treated trypsin in rabbits. An increase in the readily activated protease fraction of plasma is observed after adding the treated enzyme to plasma in vitro and after injecting it intraven.

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