Glycogen Fractions of Cardiac Muscle in the Normal and Anoxic Heart

Publisher Website
Google Scholar
Abstract
The total and trichloroacetic acid (TCA)-soluble glycogen of the heart was determined on normal dogs and dogs that died of pneumothorax-induced anoxia. Total cardiac glycogen decreased in the anoxic condition but TCA-soluble glycogen decreased to an even greater degree, indicating conversion of the TCA-soluble fraction to residual glycogen. A similar condition was found to develop in excised hearts of dogs 1 hour after removal from the body. However, 2.5 hours after excision of the heart, the percentage of TCA-soluble glycogen began to increase and continued to increase for at least 7.5 hours, even though the total glycogen was continuing to disappear. Analysis of the hearts of 4 spp. for the 2 forms of glycogen revealed considerable species variation. The heart of the goldfish has approximately 100% of the glycogen in the TCA form. The dog has 87%, the albino rat 55% and the white mouse 19% in this state. Data are thought to add support to the concept that these 2 forms of glycogen are true physiological entities.

This publication has 5 references indexed in Scilit: