Syntheses of coriolin, 1-deoxy-1-ketocoriolin and 1,8-dideoxy-1,8-diketocoriolin from coriolin B.
- 1 January 1980
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (4) , 404-407
- https://doi.org/10.7164/antibiotics.33.404
Abstract
Hydrolysis of 5,8-di-O-tetrahydropyranyl-5-deoxo-5-hydroxycoriolin which was prepared from coriolin B, followed by oxidation of the hydroxy groups at C-5, or C-1 and C-5, or C-1, C-5 and C-8 afforded coriolin (2), 1-deoxy-1-ketocoriolin (3) and 1,8-dideoxy-1,8-diketocoriolin (4). All 3 ketones had antitumor activity, while antibacterial activity was observed in 2 and 3 but not in 4.This publication has 2 references indexed in Scilit:
- Chemical modification of the ester group of diketocoriolin B.The Journal of Antibiotics, 1980
- Chemical modification of coriolin B.The Journal of Antibiotics, 1977