Carbohydrate-based combinatorial libraries
- 1 January 1998
- journal article
- review article
- Published by Springer Nature in Molecular Diversity
- Vol. 3 (2) , 75-94
- https://doi.org/10.1023/a:1009650424835
Abstract
Carbohydrate-based combinatorial libraries are tremendously valuable for studying the role of sugars in biology and for expanding accessible molecular diversity needed in broad-based drug screening programs. This review discusses the issues that are relevant to the successful implementation of comprehensive carbohydrate-based combinatorial library programs. In addition, details of oligosaccharide and glycoconjugate libraries constructed using both solid phase and solution phase strategies are presented.Keywords
This publication has 18 references indexed in Scilit:
- Multiple Column Synthesis of a Library of T‐Cell Stimulating Tn‐Antigenic Glycopeptide Analogues for the Molecular Characterization of T‐Cell–Glycan SpecificityJournal of Peptide Science, 1996
- Synthesis and Applications of Small Molecule LibrariesChemical Reviews, 1996
- A Strategy for a Convergent Synthesis of N-Linked Glycopeptides on a Solid SupportScience, 1995
- Strategies for the Synthesis and Screening of Glycoconjugates. 2. Covalent Immobilization for Flow CytometryBioconjugate Chemistry, 1995
- Strategies for the Synthesis and Screening of Glycoconjugates. 1. A Library of GlycosylaminesBioconjugate Chemistry, 1995
- Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future DirectionsJournal of Medicinal Chemistry, 1994
- Solid‐phase synthesis of O‐mannosylated peptides: two strategies comparedInternational Journal of Peptide and Protein Research, 1993
- GLYCOBIOLOGYAnnual Review of Biochemistry, 1988
- Oligosaccharide synthesis on a light-sensitive solid support. I. Polymer and synthesis of isomaltose (6-O-.alpha.-D-glucopyranosyl-D-glucose)Journal of the American Chemical Society, 1973
- Synthesis of oligosaccharides on polymer supports. Part I. 6-O-(p-vinylbenzoyl) derivatives of glucopyranose and their copolymers with styreneJournal of the Chemical Society C: Organic, 1971