Effects of Adrenocorticotrophic Hormone on Neuro-Muscular Function in Patients with Myasthenia Gravis.
- 1 July 1949
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 71 (3) , 432-435
- https://doi.org/10.3181/00379727-71-17213
Abstract
Admn. of adrenocorticotrophic hormone (ACTH) to patients with myasthenia gravis was first begun in 1944 by Torda and Wolff. In this investigation, 5 patients moderately to severely ill with myasthenia gravis, were given 400 mg. of ACTH in 20 mg. amts. every 6 hrs. Changes suggestive of incomplete remission followed ACTH admn. These changes included decrease of symptoms and outward manifestations of muscle dysfunction, disappearance of abnormalities noted in the electromyogram, increased work performance on the ergograph, and increase to normal of the ability of serum to support acetylcholine synthesis. The incomplete remission is long lasting.Keywords
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