ENDOCRINE THERAPY OF FUNCTIONAL MENO-METRORRHAGIA AND OVARIAN STERILITY I. THE CYCLIC ADMINISTRATION BY INJECTION OF ESTROGENS AND PROGESTERONE1

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Abstract
Women (51), av. age 22.7 years, with menometrorrhagia and ovarian sterility characterized by bleeding from estrogenic endometria were treated by the cyclic adm. of estrogens and progesterone. A total of 217 cycles of therapy was given an av. of 4.2 cycles per patient. Immediate responses to therapy were judged by alterations in the duration and cyclicity of bleeding and by specific responses of the endometria, as evidenced by biopsies taken at the onset of bleeding. Ultimate therapeutic salvage was evaluated by the continuation of cyclic bleeding, spontaneous recurrence of normal ovario-endometrial cycles and the occurrence of pregnancies after the discontinuation of therapy. Some patients fulfilled all these criteria for therapeutic salvage and 45.5% of the patients showed spontaneous progestational cycles. In this group there were 4 normal pregnancies. The modus operandi of this form of therapy is discussed. It is suggested that therapeutic salvage is due to a favorable influence of the sterols on some theoretical endometriopathic disturbance in sterol metabolism.