GENETIC STUDY OF HEMOGLOBIN VARIANTS IN MICE (MUS MUSCULUS)

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Abstract
Electrophoretic patterns of adult hemoglobins from two mouse strains, PON and Mol-A, are controlled by Hbbd, an allele found only in a strain, AU/SsJ. Fresh hemolysate from Hbbs/Hbbs mouse possesses a single hemoglobin, and the hemolysates from Hbbd/Hbbd and Hbbp/Hbbp mice contain two different hemoglobins in unequal amounts. The hemoglobin of s homolysate is different from each of the major and minor hemoglobins of d and p, and the difference of hemoglobins between d and p is observed in the minor hemoglobin. All differences among these are derived from multiple allelic genes at one locus, which determines the structure of the hemoglobin β-chain polypeptide.