IGG SUBCLASS DISTRIBUTION OF AUTOANTIBODIES TO DNA AND TO NUCLEAR RIBONUCLEOPROTEINS IN AUTOIMMUNE-DISEASES

  • 1 January 1984
    • journal article
    • research article
    • Vol. 51  (3) , 595-600
Abstract
Serum samples (57) positive for antibodies to double-stranded DNA (dsDNA), single-stranded DNA (ssDNA) or small nuclear ribonucleoproteins (snRNP) selected from patients with systemic lupus erythematosus and mixed connective tissue disease, were examined for the IgG subclass distribution of these autoantibodies. Antibodies to dsDNA were relatively restricted to IgG1 and IgG3 subclasses while antibodies to ssDNA were equally distributed throughout the 4 subclasses. Antibodies to snRNP were essentially restricted to the IgG2 isotype. These isotype distribution patterns contrasted with that observed for total serum IgG.

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