Sequences flanking the repeat arrays of human minlsatellites: association with tandem and dispersed repeat elements
- 11 July 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 17 (13) , 4925-4936
- https://doi.org/10.1093/nar/17.13.4925
Abstract
We present DNA sequences flanking cloned hypervariable human minisatellites. In addition to providing confirmatory evidence that minisatellites cluster with other tandem repeats, these flanking sequences contain a high frequency of interspersed repetitive elements. These elements include a retroviral LTR-like sequence, from which one of the minisatellites appears to have expanded, and a recently described short interspersed repeat. We present our own findings concerning this element, in particular that those examples studied do not show significant evolutionary conservation, despite suggestions that the element may have a cis-acting function.Keywords
This publication has 27 references indexed in Scilit:
- Twelve loci form a continuous linkage map for human chromosome 18Genomics, 1988
- A primary map of ten DNA markers and two serological markers for human chromosome 19Genomics, 1988
- Characterization of a panel of highly variable minisatellites cloned from human DNAAnnals of Human Genetics, 1987
- Variable Number of Tandem Repeat (VNTR) Markers for Human Gene MappingScience, 1987
- Positive identification of an immigration test-case using human DNA fingerprintsNature, 1985
- Individual-specific ‘fingerprints’ of human DNANature, 1985
- Rapid and Sensitive Protein Similarity SearchesScience, 1985
- Hypervariable ‘minisatellite’ regions in human DNANature, 1985
- The Alu Family of Dispersed Repetitive SequencesScience, 1982
- Trans-complementable copy-number mutants of plasmid ColE1Nature, 1980