HYPERVITAMINOSIS A

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Abstract
The paucity of published reports of hypervitaminosis A indicates the relatively low incidence of this syndrome. However, the increasing number of publications about the symptom complex since Josephs'1 article in 1944 suggests that many cases of clinical hypervitaminosis A may have been overlooked in the past. Prompted by new findings, leading medical journals on each side of the Atlantic Ocean recently have had editorials on the subject.2 In addition to Josephs' description, Toomey and Morissette,3 Rothman and Leon,4 Fried and Grand,5 Dickey and Bradley,6 Wyatt, Carabello and Fletcher7 and Caffey8 have presented additional material concerning the now well established syndrome of hypervitaminosis A in man. Furthermore, experiments on laboratory animals given large doses of vitamin A have not only helped to delineate the clinical signs but, of greater importance, have provided material for the study of physiological, chemical and histological changes induced
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