Limits of ABR and contribution of transtympanic electrocochleography in the assessment of cerebellopontine angle tumours

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Abstract
Auditory brainstem responses (ABR) and transtympanic electrocochleography (ECochG) were analysed for 63 patients with tumours of the cerbellopontine angle (CPA) and/or internal auditory meatus (IAM). ABR recordings indicated a clearly prolonged wave I-V interval (above 4.3 ms) in half of the patients, hence suggesting a retrocochlear disorder. For the remaining patients ABR alone was not sufficient for clear diagnosis and ECochG was therefore used in addition. When the latency of wave V was uncertain due to the absence of wave I, the latency of wave N1 was always measurable by EChochG. The NI-V interval evaluated in this way was always significantly prolonged (above 4.5 ms) relative to a control group of patients with a sensorineural hearing loss. In 9 of the 13 subjects without any discernible ABR, an ECochG response could be recorded and its threshold was often better than the mean pure tone audiogram. This study confirms the validity of transtympanic ECochG in the diagnosis of retrocochlear disorders. The time difference observed between wave N1 (ECochG) and wave I (ABR) in CPA tumours is discussed and a possible explanation is proposed.

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