Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in walker cells
- 1 November 1989
- journal article
- research article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 38 (22) , 4137-4143
- https://doi.org/10.1016/0006-2952(89)90695-3
Abstract
No abstract availableThis publication has 22 references indexed in Scilit:
- The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)Biochemical Pharmacology, 1988
- A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in walker carcinoma cellsBiochemical Pharmacology, 1988
- DT-diaphorase activity and the cytotoxicity of quinones in C3H/10T1/2 mouse embryo cellsBiochemical Pharmacology, 1988
- CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cellsBiochemical and Biophysical Research Communications, 1986
- Caffeine inhibition of the metabolic activation of a carcinogen, 4-nitroquinoline-1-oxide, in cultured Chinese hamster cellsCarcinogenesis: Integrative Cancer Research, 1984
- Studies on the protection by imidazoles against the cytotoxicity of the antitumour alkylating agents melphalan and CB 1954Biochemical Pharmacology, 1976
- Protection against the effects of the antitumour agent CB 1954 by certain imidazoles and related compoundsBiochemical Pharmacology, 1975
- Studies on the reversal of the selective antitumour effect of the aziridinyl derivative cb 1954 by 4‐amino‐5‐imidazolecarboxamideInternational Journal of Cancer, 1972
- Serum-mediated Immunological Non-reactivity between Histoincompatible Cells in Tetraparental MiceNature, 1971
- 2,4-Dinitro-5-ethyleneiminobenzamide (CB 1954): A potent and selective inhibitor of the growth of the Walker carcinoma 256Biochemical Pharmacology, 1969