Epicardial Stenosis Severity Does Not Affect Minimal Microcirculatory Resistance
- 12 October 2004
- journal article
- Published by Wolters Kluwer Health in Circulation
- Vol. 110 (15) , 2137-2142
- https://doi.org/10.1161/01.cir.0000143893.18451.0e
Abstract
Background— Whether minimal microvascular resistance of the myocardium is affected by the presence of an epicardial stenosis is controversial. Recently, an index of microcirculatory resistance (IMR) was developed that is based on combined measurements of distal coronary pressure and thermodilution-derived mean transit time. In normal coronary arteries, IMR correlates well with true microvascular resistance. However, to be applicable in the case of an epicardial stenosis, IMR should account for collateral flow. We investigated the feasibility of determining IMR in humans and tested the hypothesis that microvascular resistance is independent of epicardial stenosis.Keywords
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