ESTROGENIC LEYDIG-CELL TUMOR WITH MULTIPLE METASTASES IN A DOG. THE PROBLEM OF BISEXUAL HORMONE PRODUCTION BY GONADAL CELLS

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Abstract
Testicular tumors in dogs are of interest because of their high incidence (1–5) and the light they shed on the hormonal activity of the various cell types occurring in the testes of man. Proof has been amassed within recent years that the Sertoli cells and their respective tumors can produce estrogenic hormone (6–9). The outstanding feature described in this report is that a canine Leydigcell tumor can: (a) produce estrogenic hormone, as does the canine Sertolicell tumor, (b) induce excessive feminization, and (c) give ise to metastases in the brain.