Effects of Diamox on epileptic monkeys

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Abstract
It has been postulated that stretching of cortical dendrites may influence the activity at a cortical epileptogenic focus. Since Diamox (acetazoleamide) increases brain volume, dendrite stretching at the cortical scar might result, Epilepsy was induced in 8 monkeys by the alumina cream method. Continuous eeg recording was carried out during and after the intravenous administration of Diamox. No significant alteration of the eeg was seen in any of these animals. The possible mechanisms participating in this phenomenon are discussed.