Studies on peptides. CXXIV. Solution synthesis of the hentetracontapeptide amide corresponding to the entire amino acid sequence of human corticotropin releasing factor (hCRF).

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Abstract
The hentetracontapeptide amide corresponding to the entire amino acid sequence of human corticotropin releasing factor (hCRF), deduced from the complementary DNA (cDNA) sequence analysis, was synthesized by assembling 9 peptide fragments in solution followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole (molar ratio 1:1) in trifluoroacetic acid. The synthetic peptide significantly elevated the immunoreactive corticotropin level in rat plasma.