Myoglobin Subfractions: Abnormality in Duchenne Type of Progressive Muscular Dystrophy
- 16 February 1968
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 159 (3816) , 736-737
- https://doi.org/10.1126/science.159.3816.736
Abstract
Human metmyoglobin was separated electrophoretically into four subfractions: Mb1, Mb2, Mb3, and Mb4, which divide into at least two biochemically independent groups: Mb1 and Mb2, and Mb3, and Mb4. In normal subjects, Mb1 constituted the predominant component; Mb2, Mb3, and Mb4 were the minor components in this descending order. In the Duchenne type of progressive muscular dystrophy, on the contrary, a remarkable decrease in Mb1 and a concomitant increase in Mb3 were observed. This unique abnormality in the relative distribution of myoglobin subfractions was recognized only in the Duchenne type and not in other types of progressive muscular dystrophy or in other myopathies.This publication has 6 references indexed in Scilit:
- Studies of Human Myoglobin in Several Diseases of MuscleNew England Journal of Medicine, 1964
- A Study of Myoglobin in Disease with Comments Concerning the Myoglobin Minor ComponentsCold Spring Harbor Symposia on Quantitative Biology, 1964
- Abnormal Myoglobin Ultraviolet Spectrum in Duchenne Type of Progressive Muscular DystrophyScience, 1963
- The Characterization of Adult Human MyoglobinJournal of Biological Chemistry, 1962
- Heterogeneity of human myoglobinArchives of Biochemistry and Biophysics, 1956