Negative regulation of airway responsiveness that is dependent on γδ T cells and independent of αβ T cells
- 1 October 1999
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 5 (10) , 1150-1156
- https://doi.org/10.1038/13476
Abstract
The mechanisms regulating airway function are complex and still poorly understood. In diseases such as asthma, involvement of immune-dependent mechanisms has been suggested in causing changes in airway responsiveness to bronchoconstrictors. We now demonstrate that γδ T cells can regulate airway function in an αβ T cell-independent manner, identifying them as important cells in pulmonary homeostasis. This function of γδ T cells differs from previously described immune-dependent mechanisms and may reflect their interaction with innate systems of host defense.Keywords
This publication has 29 references indexed in Scilit:
- The immune system evolved to discriminate infectious nonself from noninfectious selfPublished by Elsevier ,2003
- Nonatopic asthma: in vivo airway hyperreactivity adoptively transferred to naive mice by THY-1(+) and B220(+) antigen-specific cells that lack surface expression of CD3.Journal of Clinical Investigation, 1997
- Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice.Journal of Clinical Investigation, 1996
- Regulation of T‐cell activation in the lung: alveolar macrophages induce reversible T‐cell anergy in vitro associated with inhibition of interleukin‐2 receptor signal transductionImmunology, 1996
- Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice.The Journal of Experimental Medicine, 1996
- Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.The Journal of Experimental Medicine, 1996
- Regulation of IgE Responses to Inhaled Antigen in Mice by Antigen-Specific γδ T CellsScience, 1994
- Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogenNature, 1993
- Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stagesNature, 1992
- Resident pulmonary lymphocytes expressing the γ/δ T-cell receptorNature, 1989