Improved synthesis and resolution of β‐(3‐pyridyl)‐DL‐α‐alanine

1 September 1984

journal article
research article
Published by Wiley in International Journal of Peptide and Protein Research

Vol. 24 (3) , 197-200
https://doi.org/10.1111/j.1399-3011.1984.tb00947.x

Abstract

β‐Benzamido‐α‐(3‐pyridyl)‐DL‐α‐alanine hydrochloride was synthesized from 3‐pyridinecarboxyaldehyde via the azlactone which was hydrolyzed to the acrylic acid before hydrogenation. The methyl ester was effectively resolved with subtilisin. The optical purity of the D‐isomer was established, since the D‐isomer was used in synthesis of antagonists of the luteinizing hormone releasing hormone.

Keywords

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