METABOLISM OF CARBAMAZEPINE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 10  (1) , 1-10
Abstract
Metabolites (32) of carbamazepine [used in treatment of epilepsy and trigeminal neuralgia], in addition to the 10,11-epoxide, were isolated from enzymatically hydrolyzed urine by HPLC and identified by gas-chromatographic and mass-spectrometric techniques. Eight were sulfur-containing methylthio, methylsulfonyl, methylsulfinyl, or derivatives. New metabolites (18), including 5 iminostilbene derivatives that have not been described earlier, were found. All of the metabolites were formed by processes involving epoxidation and a peroxidation, and the structure of the metabolites support the hypothesis that multiple epoxides and a cyclic peroxide are involved in the in vivo metabolism of carbamazepine by the rat and man.