Variant Multiple Endocrine Neoplasia I (MEN IBurin): Further Studies and Non-Linkage to HLA
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Human Heredity
- Vol. 35 (1) , 15-20
- https://doi.org/10.1159/000153508
Abstract
We have extended our study of an incomplete variant of multiple endocrine neoplasia Type I (MEN IBurin). In this syndrome, primary hyperparathyroidism and prolactin-secreting adenoma are common, with hormone-secreting pancreatic tumors being rarely seen. The recent localization of the prolactin structural gene to chromosome 6 made further investigation of linkage to HLA of particular interest. Results in 2 multigeneration families exclude close linkage to HLA. We cannot at this time draw any inference regarding linkage of MEN IBurin to the prolactin structural gene.Keywords
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