THE EFFECT OF A SINGLE DOSE OF THYROTROPHIN ON THE UPTAKE OF P32 BY THE GUINEA-PIG THYROID

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Abstract
The effect of a single dose of thytropin on the percentage of epithelium, the rate of mitosis, and the uptake of P32 in the thyroid was studied. The histological reaction reached a maximum 8 hours after injection of TSH. In the previous study, a maximum at 2 hours was observed using another TSH preparation. Uptake of p32 exhibited maxima at 1 hour and 8 hours after injection. After the 4 hour point, the histological curve and the uptake curve ran parallel. Results indicate that there is a fundamental difference between these 2 end reactions. The rate of mitosis did not increase during the experlment.