Chemoimmunoprophylaxis of an Experimental Bladder Cancer with Retinoids and Bacillus Calmette Guérin

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Abstract
The prophylactic effect of 2 retinoids (Ro 4-3780 [13-cis-retinoic acid] and Ro 10-9359 [all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid ethyl ester]), alone or in combination with BCG, was studied in an experimental murine bladder tumor [MBT-2 cells] model. The incidence of tumor takes in all treatment groups was lower than in the control group. Both BCG and Ro 10-9359 were effective in decreasing the percentage of tumor takes; the simultaneous use of these agents was more effective than either one alone. Ro-10-9359 possessed more antitumor activity than Ro 4-3780 in this tumor model. Treatment of mice with a combination of Ro 10-9359 and BCG resulted in an 83.3% incidence of complete tumor regression within 80 days. Vitamin A derivatives may be useful in the prevention and treatment of bladder cancer; the activity is likely potentiated by nonspecific stimulation.