Immunoprophylaxis of a Murine Bladder Cancer with High Dose Bcg Immunizations

Publisher Website
Google Scholar
Abstract
The immunoprophylactic effect of Mycobacterium bovis, strain Bacillus Calmette-Guerin (BCG) was studied in a syngeneic bladder tumor system. Injection of a high dose of viable BCG 10 days before tumor cell challenge induced a 46% reduction in tumor take. No protection against tumor take was afforded by the simultaneous administration of BCG and tumor cells. Complete tumor regression was observed in a number of animals (mouse) of the 2 groups receiving BCG: 90% in the group receiving the vaccine and the tumor simultaneously and 50% in those being immunized 10 days before tumor challenge. Apparently high dose, viable BCG immunization favorably alters the course of this experimental tumor.