ACYLPOLYAMINES MIMIC THE ACTION OF JORO SPIDER TOXIN (JSTX) ON CRUSTACEAN MUSCLE GLUTAMATE RECEPTORS

Publisher Website
Google Scholar
Abstract
Effects of 10 synthetic compounds structurally related to spider toxins were studied on the glutamate receptors in crustacean neuromuscular synapses. The asparaginyl cadaverine moiety located in the middle part of JSTX-3 molecule is found to be unnecessary for the activity, since the aromatic or aliphatic part attached directly to the terminal amino group of spermine through an amido-bond mimics the blocking action on JSTX-3 on the lobster neuromuscular synapse. All such synthetic compounds are active to varying extents and recovery from the inhibitory action could be achieved by washing the preparation. The most potent synthetic compound was 1-naphthylacetyl spermine (approximately 1/10 of JSTX-3) which may be useful as a probe for studies on this type of glutamate receptor.