Involvement of three intracellular messenger systems, protein kinase C, calcium ion and cyclic AMP, in the regulation of c‐fos gene expression in Swiss 3T3 cells
- 10 November 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 208 (1) , 39-42
- https://doi.org/10.1016/0014-5793(86)81527-7
Abstract
In quiescent cultures of Swiss 3T3 cells, platelet-derived growth factor or fibroblast growth factor known to induce both protein kinase C activation and Ca2+ mobilization raised c-fos mRNA. This action of the growth factors was mimicked by the specific activators for protein kinase C, such as phorbol esters and a membrane-permeable synthetic diacylglycerol, and also by the Ca2+ ionophores, such as A23187 and ionomycin. Prostaglandin E1 known to elevate cyclic AMP also raised c-fos mRNA, and this action was mimicked by 8-bromo-cyclic AMP, dibutyryl cyclic AMP and forskolin. These results suggest that expression of the c-fos gene is regulated by three different intracellular messenger systems, protein kinase C, Ca2+ and cyclic AMP, in Swiss 3T3 cellsKeywords
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