Chemical mutagenesis testing in Drosophila. III. Results of 48 coded compounds tested for the national toxicology program
- 1 January 1985
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 7 (3) , 325-348
- https://doi.org/10.1002/em.2860070309
Abstract
Forty‐eight chemicals were tested for mutagenicity in Drosophila melanogaster. Each compound was tested first for the induction of sex‐linked recessive lethals (SLRLs) by feeding the chemical in a solution of 5% aqueous sucrose. If it was not mutagenic by this route, the chemical was tested by injection in a solution of 0.7% aqueous NaCl. If found inactive, the compound was not tested further. If it was mutagenic, the compound was tested for the induction of reciprocal translocations (RTs) using the exposure protocol and germ cell stage that yielded positive results in the SLRL assay. Eight chemicals (diglycidylresorcinol ether, AF‐2, alloxan monohydrate, 1‐aziridine ethanol, p,p'‐DDE, dichloroacetonitrile, 1,3‐dichloropropene, and 3,3′‐dimethylbenzidine dihydrochloride) were found to induce SLRLs. Only diglycidylresorcinol ether also induced RTs.Keywords
This publication has 18 references indexed in Scilit:
- Tables for determining the statistical significance of mutation frequenciesPublished by Elsevier ,2003
- Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the national toxicology programEnvironmental Mutagenesis, 1985
- Chemical mutagenesis testing in Drosophila: I. Comparison of positive and negative control data for sex‐linked recessive lethal mutations and reciprocal translocations in three laboratoriesEnvironmental Mutagenesis, 1983
- AN OVERVIEW OF GENETIC TOXICITY TESTING IN THE NATIONAL TOXICOLOGY PROGRAMAnnals of the New York Academy of Sciences, 1983
- The mei‐9a test for chromosome loss in drosophila: A review of assays of 21 chemicals for chromosome breakageEnvironmental Mutagenesis, 1983
- Toxicity and mutagenicity of cadmium and furylfuramide in Drosophila melanogaster.The Japanese Journal of Genetics, 1978
- Mutagenicity testing of H-193, AF-2 and furazolidone in Drosophila melanogasterMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977
- Mutagenitätsuntersuchungen mit DDT und den DDT-metaboliten DDE, DDD, DDOM und DDA anDrosophilia melanogasterMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972
- Mutations in Drosophila after Chemical Treatment of Gonads In vitroNature, 1946
- Production of Mutations by Allyl IsothiocyanateNature, 1944