Total synthesis of both (+)-compactin and (+)-mevinolin. A general strategy based on the use of a special titanium reagent for dicarbonyl coupling
- 31 March 1990
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 112 (8) , 3018-3028
- https://doi.org/10.1021/ja00164a024
Abstract
No abstract availableThis publication has 34 references indexed in Scilit:
- Total synthesis of the hypocholesterolemic agent compactinJournal of the American Chemical Society, 1983
- Regio- and stereocontrolled synthesis of epoxy alcohols and triols from allylic and homoallylic alcohols via iodocarbonatesThe Journal of Organic Chemistry, 1982
- Effects of an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase on Serum Lipoproteins and Ubiquinone-10 Levels in Patients with Familial HypercholesterolemiaNew England Journal of Medicine, 1981
- Dihydromevinolin,a potent hypocholesterolemic metabolite produced by Aspergillus terreus.The Journal of Antibiotics, 1981
- Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the ReductaseJournal of Clinical Investigation, 1980
- Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.Proceedings of the National Academy of Sciences, 1980
- Kinetic Analysis of the Reaction Catalyzed by Rat‐Liver 3‐Hydroxy‐3‐methylglutaryl‐coenzyme‐A Reductase Using Two Specific InhibitorsEuropean Journal of Biochemistry, 1979
- Inhibitory Effects on Lipid Metabolismn in Cultured Cells of ML‐236B, a Potent Inhibitor of 3‐Hydroxt‐3‐methylglutaryl‐Cornzyme‐A ReductaseEuropean Journal of Biochemistry, 1978
- Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductaseJournal of Biological Chemistry, 1978
- Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactumJournal of the Chemical Society, Perkin Transactions 1, 1976