The Saccharomyces cerevisiae SPT13/GAL11 gene has both positive and negative regulatory roles in transcription.
Open Access
- 1 December 1989
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 9 (12) , 5602-5609
- https://doi.org/10.1128/mcb.9.12.5602
Abstract
To understand the function of SPT13, a gene encoding a trans-acting factor involved in regulation of Ty-mediated gene expression, we have cloned and sequenced the gene. Our analysis revealed that SPT13 is the same gene as GAL11, a gene in which mutations cause reduced expression of some GAL4-regulated genes. Further analysis of spt13/gal11 mutants suggested that the SPT13 gene also affects transcription of genes involved in mating-type specialization. We show here that SPT13 has both positive and negative regulatory roles in transcription.This publication has 66 references indexed in Scilit:
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