THE INFLUENCE OF ORAL ASCORBIC ACID ADMINISTRATION ON THE ADRENAL CORTICAL RESPONSE TO ACTH
- 1 June 1951
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Medical Sciences
- Vol. 29 (3) , 100-103
- https://doi.org/10.1139/cjms51-012
Abstract
The effect of orally administered ascorbic acid (as sodium ascorbate) on the adrenal cortical response to ACTH was studied in the hypophysectomized male rat. Plasma and adrenal ascorbic acid and adrenal cholesterol levels were determined three and six hours after ACTH injection. The depletion of adrenal ascorbic acid following such treatment was partially inhibited by the adminis tration of sodium ascorbate while the decrease in cholesterol was unaffected. These results suggest that the uptake of ascorbic acid from the increased quantity available in the plasma was sufficient to partially overcome the depleting effect of ACTH.Keywords
This publication has 2 references indexed in Scilit:
- Influence of Adrenaline and Insulin on Adrenal Cortical Response to ACTHExperimental Biology and Medicine, 1951
- THE EFFECT OF GLUCOSE ON THE ADRENAL RESPONSE TO ACTH IN HYPOPHYSECTOMIZED RATSEndocrinology, 1950