Plasma Lipids and Coagulation of Blood

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Abstract
Coagulation studies were performed on 7 controls, 6 persons with idiopathic hyperlipemia, and 5 persons with idiopathic hypercholesteremia. In addition, most of the patients were retested after a standard meal of fat. In none of the persons was there an alteration of the standard clotting time, 3-tube silicone clotting time, standard prothrombin time, serum prothrombin activity, thrombin generation, and thromboplastin generation. Depending upon the content of triglyceride, there was a distinct difference in the behavior of various plasmas to the action of "incomplete" thromboplastin (Stypven). Stypven prothrombin time was definitely shorter in 4 of 5 healthy controls after the ingestion of fat. In the one who did not have a shorter time, the expected rise in serum triglycerides (neutral fat) failed to occur. In the persons with idiopathic hyperlipemia, Stypven prothrombin times were abnormally shortened prior to the ingestion of fat, and they were only slightly altered after the meal of fat. In the persons with idiopathic hypercholesteremia, the Stypven prothrombin time was similar to that observed in the controls. Chemical and electrophoretic studies revealed that reduction in the Stypven prothrombin time was correlated with an increase in serum triglycerides. Centrifugation of hyperlipemic plasma into 2 fractions, fat-rich and fat-poor, also revealed a correlation between the content of fat and reduction of the Stypven prothrombin time. No change in erythro-cytic fragility (osmotic or mechanical) was observed after the ingestion of food. Intact platelets and disrupted platelets, even more so, exerted an effect similar to that of triglycerides, in that they shortened the Stypven prothrombin time. A thromboplastin potentiator (triglyceride) in the plasma, either postprandially in normal persons or, perhaps more important, constantly in hyperlipemic persons, may result in increased coagulability and thrombosis when thromboplastic material is liberated into the blood stream.

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