VARIATIONS IN THE EXTRACTION OF UREA BY THE KIDNEY AND THEIR RELATION TO THE AMOUNT OF UREA REABSORBED

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Abstract
The following conclusions were based upon data from 50 exps. in one-kidney dogs in which the kidney was explanted by a modified Rhoads technique to insure collection of uncontaminated blood from the renal vein. Momentary variations in the extraction percentage of urea are dependent chiefly upon changes in the rate at which urea is reabsorbed, and to a relatively unimportant degree upon changes in the rate of filtration. The rate of reabsorption varies from none to all of the filtered urea and the average lies between 40 and 50%; this average is usually approximated within any period of 30-60 min. Cessation of the extraction of urea due to cessation of filtration can occur in association with anuria. Increase in urea concn. of the blood in the kidney does not exceed that explicable by complete reabsorption of filtered urea. It is postulated that extreme fluctuations in the rate of re- absorption of urea occur independently of experimental procedures.

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