Proteins Induced by Boolarra Virus in Drosophila melanogaster Line 1 Cells

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Abstract
In Boolarra virus infected Drosophila line 1 cells five virus-induced proteins were readily detected 20 h postinfection. These were A (103,500), α (46,000), β (40,000), B (9,600), and γ (6,600) and are similar in molecular weight to those induced in vivo by other nodaviruses. The addition of actinomycin D for the 1st h before the labeling period resulted in the production of all five proteins; but when actinomycin D was introduced for the entire labeling period, the synthesis of the products of RNAl was greatly reduced. Host functions inhibited by actinomycin D may play a major role in the replication of this virus.