Pharmacological study on Panax ginseng C.A. Meyer. IV. Effects of red ginseng on experimental disseminated intravascular coagulation. 3. Effect of ginsenoside-Ro on the blood coagulative and fibrinolytic system.

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Abstract
The antithrombic activity of ginsenoside-Ro isolated from the roots of Panax ginseng C. A. Meyer was evaluated in experimental models of disseminated intravascular coagulation (DIC) induced by infusion of endotoxin or thrombin in rats. Ginsenoside-Ro (50 mg/kg, p.o.) prevented the decrease of fibrinogen in endotoxin-induced DIC. Ginsenoside-Ro also inhibited the formation of fibrin thrombi in the renal glomeruli in thrombin-induced DIC. Ginsenoside-Ro showed a promotive effect on the activation of the fibrinolytic system as determined by the euglobin lysis time (ELT) assay. The promotive effect of ginsenoside-Ro on the activation of the fibrinolytic system was inhibited by pretreatment with .epsilon.-aminocaproic acid (an anti-plasmin agent), but not by pretreatment with promethazine or cyproheptadine (anti-chemical agents).