STUDIES ON VI ANTIGEN
- 1 July 1954
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 60 (1) , 52-62
- https://doi.org/10.1093/oxfordjournals.aje.a119703
Abstract
A study was made of the immunological response of human beings to purified Vi antigen derived from Escherichia coli 5396/38. Of a total of 432 subjects given a single subcut. injn. of 0.04 mg. of antigen, 95% developed Vi antibody. Larger amts. or multiple injns. of antigen failed to increase antibody levels. Antibody developed in response to a single small injn. persisted for periods up to 2 yrs.. This was contrasted with the rapid disappearance of Vi antibody following recovery from typhoid fever. Similarities in the response of man to the pneumococcal polysaccharides and the Vi antigen are pointed out and discussed.Keywords
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