Dynamic Kinetic Resolution of Amines Involving Biocatalysis and in Situ Free Radical Mediated Racemization
- 6 February 2007
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 9 (5) , 837-839
- https://doi.org/10.1021/ol063062o
Abstract
The association of lipase-catalyzed enzymatic resolution with in situ racemization mediated with the thiyl radical enables the dynamic kinetic resolution of non-benzylic amines. It leads to (R)-amides with high enantioselectivities. It can be applied either to the conversion of racemic mixtures or to the inversion of (S)-enantiomers.Keywords
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