The effect of cholesterol feeding on lipoid deposition in the liver of rats

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Abstract
On a diet causing "fat" fatty livers in rats, the degree of glyceride infiltration is proportional to the amt. of fat in the diet. A small increase in the amt. of cholesteryl esters does not appear to be related to the % of fat in the diet. On a diet causing "cholesterol" fatty livers, successive increases in the % of fat in the diet cause progressive and large increases in the cholesteryl ester content of the liver. Very considerable increases in the amts. of glyceride also occur, and the "cholesterol" fatty liver always contains much more glyceride than the "fat" fatty liver at any given level of dietary fat. Small increases in the amts. of free cholesterol also occur with increases in the amt. of dietary fats, and these become greater when cholesterol is present in the diets.