Validation of a rapid microtiter plate assay to conduct cytochrome P450 2D6 enzyme inhibition studies
- 1 October 1998
- journal article
- review article
- Published by Elsevier in Drug Discovery Today
- Vol. 3 (10) , 466-470
- https://doi.org/10.1016/s1359-6446(98)01248-3
Abstract
No abstract availableKeywords
This publication has 12 references indexed in Scilit:
- Properties of cytochrome P450 isoenzymes and their substrates part 2: properties of cytochrome P450 substratesDrug Discovery Today, 1997
- Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different speciesChemico-Biological Interactions, 1997
- Microtiter Plate Assays for Inhibition of Human, Drug-Metabolizing Cytochromes P450Analytical Biochemistry, 1997
- Simultaneous Pharmacokinetic Screening of a Mixture of Compounds in the Dog Using API LC/MS/MS Analysis for Increased ThroughputJournal of Medicinal Chemistry, 1997
- The Simultaneous Determination of Mixtures of Drug Candidates by Liquid Chromatography/Atmospheric Pressure Chemical Ionization Mass Spectrometry as anIn Vivo Drug Screening ProcedureRapid Communications in Mass Spectrometry, 1997
- In Vitro techniques for studying drug metabolismJournal of Pharmacokinetics and Biopharmaceutics, 1996
- Use of in vitro human metabolism studies in drug developmentBiochemical Pharmacology, 1994
- Measurement of Liver Microsomal Cytochrome P450 (CYP2D6) Activity Using [O-methyl-14C] DextromethorphanAnalytical Biochemistry, 1994
- Simultaneous Determination of Dextromethorphan and Three Metabolites in Plasma and Urine Using High-Performance Liquid Chromatography with Application to Their Disposition in ManTherapeutic Drug Monitoring, 1990
- Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in manBiochemistry, 1988