Chlordiazepoxide and ethanol additively reduce gustatory negative contrast
- 1 April 1983
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 80 (1) , 35-37
- https://doi.org/10.1007/bf00427491
Abstract
Negative contrast that occurs when rats are shifted from 32% to 4% sucrose has been shown to be reduced by chlordiazepoxide (CDP) and ethanol (ETOH). In a previous experiment, doses of 0.75 and 1.0 g/kg ETOH substantially reduced contrast while doses of 0.25 and 0.5 g/kg ETOH were much less effective. In this study, doses of 6 and 8 mg/kg CDP were shown to attenuate the negative contrast effect while smaller doses (2 and 4 mg/kg) influenced contrast to a lesser degree. Evidence for an additive effect of CDP and ETOH on contrast reduction was obtained when 4 mg/kg CDP and 0.5 g/kg ETOH were administered together.This publication has 14 references indexed in Scilit:
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