Nonsolvent Water in Human Erythrocytes and Hemoglobin Solutions

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Abstract
Distribution ratios of water-soluble nonelectrolytes were measured for 2 systems, human red blood cells/isotonic saline and hemoglobin solutions/water. The results show that for these solutes there is a significant amount of nonsolvent water associated with hemoglobin. The amount of this nonsolvent water depends markedly on the temperature, as well as on the size, steric configuration, and functional groups of the probe solutes. The significance of the data is discussed.