Stimulation and Inhibition of Human Sweat Glands by Intradermal Sympathomimetic Agents

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Abstract
Epinephrine at concns. of 1:1000 to 1:10,000,000 causes excitation of the sweat glands of the forearm in man when injected intra-dermally. This effect is also produced by arterenol, Neo-Synephrine and isopropylarterenol. The effect is difficult to demonstrate in the palm and may even be absent at that site. The effect of epinephrine may be abolished by Dibenamine and greatly reduced by procaine. It is unaffected by atropine and tetraethylammonium. Spontaneous sweating of the forearm is unaffected by Dibenamine introduced into the skin by ion transfer. Epinephrine or acetylcho-line injd. intradermally may produce an inhibition of spontaneous sweating lasting up to 24 hrs. or longer. The significance of these observations is discussed. While the evidence supports the contention that the sweat glands of the forearm respond directly to epinephrine, the existence and function of an adrenergic inner-vation of these glands is not proven.

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