Possible Interaction between Ciprofloxacin and Warfarin
- 1 January 1990
- journal article
- case report
- Published by SAGE Publications in DICP
- Vol. 24 (1) , 27-28
- https://doi.org/10.1177/106002809002400106
Abstract
A 72-year-old man had been taking warfarin for a pulmonary embolus and recurrent deep-vein thromboses. His prothrombin times (PTs) were maintained between 15 and 18 sec (PT ratio 1.25–1.5 × control) for several months on a dose of warfarin 2.5 mg/d. Six weeks prior to starting ciprofloxacin 500 mg bid, the patient's PT was 15.5 sec (PT ratio 1.29 × control). After one week of ciprofloxacin, his PT had increased to 22 sec (PT ratio 1.83 × control). No other causes for the increase were apparent. It is recommended that patients receiving both medications have their prothrombin times carefully monitored and warfarin doses adjusted only as necessary.This publication has 9 references indexed in Scilit:
- Ciprofloxacin and WarfarinAnnals of Internal Medicine, 1989
- Norfloxacin and WarfarinAnnals of Internal Medicine, 1989
- Ofloxacin and WarfarinAnnals of Internal Medicine, 1988
- Inhibition of Drug Metabolism by Quinolone AntibioticsClinical Pharmacokinetics, 1988
- Impact of ciprofloxacin on theophylline clearance and steady-state concentrations in serumAntimicrobial Agents and Chemotherapy, 1988
- New Synthetic Quinolone Antibacterial Agents and Serum Concentration of TheophyllineChest, 1987
- Enoxacin-warfarin interaction: Pharmacokinetic and stereochemical aspectsClinical Pharmacology & Therapeutics, 1987
- Effect of multiple dose oral ciprofloxacin on the pharmacokinetics of theophylline and indocyanine greenJournal of Antimicrobial Chemotherapy, 1987
- The influence of quinolone derivatives on theophylline clearance.British Journal of Clinical Pharmacology, 1986