INCREASED INSULIN RESPONSIVENESS IN ENDOTOXICOSIS

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 6  (1) , 1-6
Abstract
The relation of endotoxicosis to insulin responsiveness was evaluated in male Holtzman rats. Salmonella enteritidis lipopolysaccharide at 0.5 or 1.0 mg/300 g rat increased lethality in convulsive seizure deaths to 0.25, 0.50 or 1.0 U [units] insulin s.c. The hypoglycemic nadir induced by 0.05, 0.10 or 0.25 U of insulin s.c. was greater in rats rendered endotoxic with 1 mg of lipopolysaccharide i.v. Oxidation of U-14C-D-glucose to 14CO2 by endotoxic tissues in vitro was augmented in liver slices, epididymal fat pads, hemidiaphragms and spleen slices; no pronounced glucose oxidation increases occurred in lung, heart, stomach, cerebrum, kidney or whole blood. Epididymal fat pads from endotoxic rats (100 g) manifested increased basal glucose oxidation and an enhanced maximal response to incremenetal insulin doses of 0.01 to 25 mU/ml. Altered tissue responsiveness in concert with hyperinsulinemia may underlie the profound alterations in glucose homeostasis during endotoxicosis.