Allergenicity of Concanavalin A in Mice

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Abstract
Concanavalin A (Con A) is a potent allergen in certain strains of mice and in particularly the H-2Kk mice, A/J, CBA/H, and C3H/He. Using a dose of 100 μg, the subcutaneous route of injection was the most effective means of inducing high, persistent titers of T cell-dependent circulating anti-Con A reagins without the addition of the classical ‘ΙgE adjuvants’, aluminium hydroxide and Bordetella pertussis vaccine. Haptenated Con A induced reagins with antihapten specificity. In the discussion, one possible contributing factor in Con A allergenicity in genetically responder strains of mice is emphasised, namely, persistence in subcutaneous injection sites.