Human Monoclonal IgG Rheumatoid Factors from the Synovial Tissue of Patients with Rheumatoid Arthritis

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Abstract
We have established IgG rheumatoid factor (RF)‐secreting hybridoma cell lines from the synovial tissues of two patients (TS and SJ) with rheumatoid arthritis (RA) und one (KL) with the polyarlicular form of juvenile rheumatoid arthritis (JRA). The IgG RF bind human and rubbit IgG and all except one form intracellular complement‐fixing complexes indicative of a self‐association process. The possibility of IgG RF for self association and immune complex formation is a feature thought to be important for the inflammatory processes in RA. Of the IgG RF‐secretingcell lines established, three clones from patient SJ and one from patient KL are of the IgG Ik isotype while five clones from patient TS are of the IgG2λ isotype.

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